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Submitted by pscully on Fri, 01/07/2011 - 10:11.
01/13/2011 - 16:10
01/13/2011 - 17:30
STA/BST 290: Wing Hung Wong, Stanford Univ.
Gene regulatory networks and stable cellular states
Thursday, January 13th, 2011 at 4.10pm, MSB 1147 (Colloquium room)
Refreshments: 3.30pm, MSB 4110 (Statistics Lounge)
Speaker: Wing Hung Wong, Stanford University
Professor of Statistics (Chair), Professor of Health Research and Policy
Title: Gene regulatory networks and stable cellular states
Abstract: A stable cell type is believed to be maintained by a set of regulators that work together, as a gene regulatory network, to control the transcriptional state of the cell. In this talk I will provide a mathematical formulation that relates the concept of a gene regulatory network to an underlying equation that governs the time evolution of the cellular state.
Based on this formulation I will outline an approach for the study of the network through gene perturbation experiments. Finally I will introduce a statistical method for the analysis of data from such perturbation experiments, and demonstrate how it works in the estimation of the gene regulatory network of embryonic stem cells.