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Submitted by pscully on Thu, 10/27/2011 - 13:40.
11/03/2011 - 16:10
11/03/2011 - 17:30
STA/BST 290: Patrice Koehl (UC Davis)
Protein structure and sequence spaces: how big are they?
Graduate Group in
Thursday, November 3rd, 2011 at 4.10pm, MSB
1147 (Colloquium Room)
Refreshments: 3.30pm, MSB 4110
Speaker: Patrice Koehl (Dept Computer Science/Genome Center, UC Davis)
structure and sequence spaces: how big are they?
family and protein structure family sizes are known to vary widely, from
orphans to considerably populated sets of far-diverged homologs.
underlying causes behind these observed irregularities in sequence space remain
unclear. In this seminar, I will show that geometry and thermodynamics are key
elements for measuring the ability of a protein to accept mutations without
losing its structure.